Alias: , hydrochloride,Dapoxe, Dapoxeti ,hy, hydrochloride
CAS No: 129938-20-1 or 119356-77-3
Appearance: White crystalline powder
Solubility:soluble in water and alcohol.
Usage: Can be used as pharmaceutical material , improves erectile function significantly, possibly increase testosterone through increased sexual activity, and it is very safe.
, marketed as (among and other brands) is the first compound developed specially for the treatment of premature ejaculation (PE) for men between18-64 years old. works by inhibiting the serotonin transporter, increasing serotonin’s action at the post synaptic cleft, so as to delay consequence ejaculation. As a member of selective serotonin reuptake inhibitor (SSRI) family, was initially created as an antidepressant. However, unlike other SSRIs, is absorbed and eliminated rapidly in the body. Its immediate response makes it suitable for the treatment of PE but not as an antidepressant.
Treat male premature ejaculation and erectile dysfunction.
Due to the lack of specific approval treatment for PE in the US and some other countries, other SSRIs such as Fluoxetine, Paroxetine, Sertraline, Fluvoxamine, and Citalopram have been used as clinical drugs to treat PE. Waldinger’s meta analysis shows that the use of these conventional antidepressants increasing IELT about 2-9 time in comparison of three to eight times when is used. However, these SSRIs must be taken daily in order to achieve meaningful efficacy, and the long half-life increases the risk of the drug accumulation and as a consequence, an increasing adverse effects such as decreasing sexual libido and causing erectile dysfunction. , on the other hand, is a fast-acting SSRI. It is rapidly absorbed and eliminated from the body within a few hours. This favorable pharmacokinetics minimizes the risk of the drug’s accumulation in the body, and therefore reducing side effects.
||White or almost white crystalline powder
||White crystalline powder
|Loss on drying
|Assay(on drled basis)
||It complies to prescribed enterprise standard
Randomized, double blind, placebocontrolled trials have confirmed the efficacy of for the treatment of PE. Different dosage has different impacts on different type of PE. 60 mg significantly improves the mean intravaginal ejaculation latency time (IELT) compared to that of 30 mg in men with lifelong PE, but there is no difference in men with acquired PE. , given 1-3 hours before sexual episode, prolongs IELT, increases the sense of control and sexual satisfaction in men of 18 to 64 years of age with PE.
Since PE is associated with personal distress, interrelationship difficulty, provides help for men with PE to overcome this condition. Because lack of specific approval treatment for PE in the US and some other countries, other SSRIs such as fluoxetine, paroxetine, sertraline, fluvoxamine, and citalopram have been used as off label drugs to treat PE. Waldingers meta analysis shows that the use of these conventional antidepressants increasing IELT from two to ninefold above base line in comparison of three to eightfold when is used.
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