99% Purity White Peptide Powder Long Arg3 IGF-1 / IGF-1 LR3 1mg/Vial For Bodybuilding
WHAT IS IGF-1 LR3?
IGF-1 LR3, also known as Long Arg3 IGF-1, is a recombinant protein analogue of human Insulin-Like Growth Factor-1 that has a molar mass of 9,200 Daltons and is comprised of 83 amino acids. IGF-1 LR3 comprises the complete IGF-1 sequence, but with a 13 amino acid extension on the B-Terminus domain and the substitution of an Arginine for the Glutamic Acid at position 3. The LR3 analogue of IGF-1 was created with the intent to drastically increase the biological activity of the protein and IGF-LR3 is several times more potent than rhIGF-1. This specific sequence alteration has decreased the affinity of binding to the IGFBPs, which control the biological actions of IGF-1 and prevent the protein from reaching the IGF-1 receptors.
IGF-1 LR3 is an 83 amino acid analogue of human IGF-1 that has been modified to include a 13 amino acid extension on its N-Terminus and the substitution of an Arginine amino acid for Glutamine at position 3. While IGF-1 LR3 is comprised of the the complete human IGF-1 sequence, these modifications have rendered the LR3 version to be much more potent than IGF-1 in-vitro and in-vivo. The result of these modifications is that IGF-1 LR3 does not bind as strongly to the IGFBPs, which modify the biological actions of IGF-1. Resultantly, IGF-1 LR3 binds to the type 1 IGF-1 receptor with similar affinity to that of wild type IGF-1, but with higher biological activity and has several advantages over recombinant insulin. The supplementation of mammalian cell cultures with Long R3 IGF-1 at a much lower concentration results in more highly elevated productivity than with standard concentrations of insulin and/or standard IGF-1. IGF-1 LR3 is better able to stimulate the type 1 IGF receptor and thus induce a higher level of activation of intracellular signaling, which is responsible for promoting cell proliferation and the inhibition of apoptosis.
Long arginine 3-IGF-1, abbreviated as IGF-1 LR3 or LR3-IGF-1, is a synthetic protein and lengthened analogue of human insulin-like growth factor 1 (IGF-1).It differs from native IGF-1 in that it possesses an arginine instead of a glutamic acid at the third position in its amino acid sequence ("arginine 3"), and also has an additional 13 amino acids at its N-terminus (MFPAMPLLSLFVN) ("long"), for a total of 83 amino acids (relative to the 70 of IGF-1). The consequences of these modifications are that IGF-1 LR3 retains the pharmacological activity of IGF-1 as an agonist of the IGF-1 receptor, has very low affinity for the insulin-like growth factor-binding proteins (IGFBPs), and has improved metabolic stability.As a result, it is approximately three times more potent than IGF-1,and possesses a significantly longer half-life of about 20-30 hours (relative to IGF-1s half-life of about 12-15 hours).
The amino acid sequence of IGF-1 LR3 is MFPAMPLSSL FVNGPRTLCG AELVDALQFV CGDRGFYFNK PTGYGSSSRR APQTGIVDEC CFRSCDLRRL EMYCAPLKPA KSA.
- enlarged amino acid transporting cells
- increased protein production
- reduced protein degradation
- amplified glucose transporting
- augmented RNA combination
IGF-1Lr3 has a half-life of about 20-30 hours and is much more potent than base IGF-1LR3. Since its half-life is about a day, the IGF-1Lr3 will circulate the body, for around 24 hours, binding to receptors and activating cell communication that improves muscle growth and fat loss.LR3 prevents glucose from entering into cells, which, in turn, forces the body to burn fat and not sucrose. In addition, its long half-life is desirable for another reason; site injections aren necessary, as IGF-1Lr3 will cycle the body binding to all muscle cells for about a day.
IG-F1 vs. HG-H
Why IGF-1LR3 and not GH? Growth hormone actually is a precursor to IGF-1LR3 Growth hormone does not directly cause muscle growth, but indirectly causes muscle growth by signaling the release of IGF-1LR3.Human Growth Hormone (HG-H) can be very expensive, and to see muscle growth it needs to be paired with insulin or other anabolic steroids. This makes IGF-1LR3 variants like LR3 and DES, which can be used as a standalone drug, a much more viable option for bodybuilder looking to see solid recovery of damaged tissue and muscle growth.
Another concern with methyl 1-test (and methylated steroids in general) is hepatotoxicity. Other substances that are toxic to the liver (such as alcohol) should be avoided to avoid placing extra stress on the liver. Milk thistle, alpha lipoic acid, and N-acetyl-cysteine are commonly recommended to help protect the liver.
When taking methyl 1-test, it is best to start out with at least a week at a dose of 5-10 mg to see how you react. Many find a lower dose to be just as effective as a higher one, but with less side effects. Most seem to find their ideal dose to be in the 10-30 mg range. Cycle length should be kept short, in the range of 1-4 weeks.
How to Storage?
- It is recommended to store metribolone at the room temperature below 30 degrees C.
- Keep the drug away from direct sunlight, heat and moisture.
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99% Purity White Peptide Powder Long Arg3 IGF-1 / IGF-1 LR3 1mg/Vial For Images