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Pharmaceutical Raw Materials Pregabalin Anti-Epileptic Drug Pregabalin

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Product Description

Pharmaceutical Raw Materials Pregabalin Anti-Epileptic Drug Pregabalin

Lyrica Ingredient Raw Material Pregabalin Pharmaceutical intermediate 99% USP

CAS: 148553-50-8
MF: C8H17NO2
MW: 159.23
Assay: 99%
Appearance: White Crystal Powder
Package: 25kg/drum
Usage: New antiepileptic drug. Used in the treatment of peripheral neuropathy, or partial seizures

Pregabalin COA:

Appearance A white to off white powder White powder
Identification A. Meets the requirement Complies
B. IR: similar to Reference Substance Complies
Loss on drying ≤0.5% 0.21%
Specific Rotation +10.0°~+13.0° +10.8°
Related Substances Any single impurity ≤0.1%
Total impurity ≤0.8%
Purity By HPLC R-isomer ≤0.15% 0.10
Residue on ignition ≤0.1% 0.05%
Residual solvents Isopropyl alcohol ≤5000ppm
Ethyl Acetate ≤5000ppm
Heavy metals ≤10ppm Complies
Chlorides ≤0.05% Complies
Assay 98%~102.0% 99.8%

Pregabalin Usage:
Pregabalin is an anticonvulsant drug used for neuropathic pain, as an adjunct therapy for partial seizures, and in generalized anxiety disorder. It was designed as a more potent successor to gabapentin.
Pregabalin is an anticonvulsant drug used for neuropathic pain, as an adjunct therapy for partial seizures, and in generalized anxiety disorder. It was designed as a more potent successor to gabapentin. Pregabalin is marketed by Pfizer under the trade nam.

Treatment by Condition Related to pregabalin:

Additional Medication to Treat Partial Seizures Medications
Neuropathic Pain Medications
Nerve Pain from Spinal Cord Injury Medications
Nerve Pain after Herpes Medications
Disorder characterized by Stiff, Tender & Painful Muscles Medications

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Antiepileptic Drus and Therapeutic Drug for Neuropathic Pain:

Pregabalin is a new antiepileptic drug, having a γ-amino butyric acid structure on its molecular structure, which has anticonvulsant effects, and is successfully developed by the company Pfizer for the treatment of peripheral neuropathic pain, or adjuvant treatment of partial seizures.
In December 2008, the US Food and Drug Administration (FDA) approved pregabalin (trade name "Lyrica") for the treatment of diabetic peripheral neuropathic pain (DPN) and postherpetic neuralgia (PHN)which are Both the most common neuropathic pains.
Neuropathic pain is one of the most difficult chronic pain syndromes to treat , dull pain, burning, tingling as the main feature, there are a lot of incentives of neuralgia, diabetes, infections (such as herpes zoster), cancer and AIDS, etc. can cause neurological pain, in Europe about 3% of the population suffer from neuralgia torture.

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Pregabalin is indicated for:

1.Treatment of neuropathic pain from diabetic neuropathy or post herpetic neuralgia. There is not enough data to state that it should be used in all neuropathic pain.
2.Adjunctive therapy in adults with partial seizures with or without secondary generalization
4.Generalized anxiety disorder
5.Alcohol Withdrawal
Usually physicians will start the patient on a low dose of pregabalin and increase it gradually, depending on the patients evaluation. Its therapeutic effect appears after 1 week of use and is similar in effectiveness to , and venlafaxine but pregabalin has demonstrated superiority by producing more consistent therapeutic effects for psychic and somatic anxiety symptoms. Long-term trials have shown continued effectiveness without the development of tolerance and additionally unlike benzodiazepines it does not disrupt sleep architecture and produces less severe cognitive and psychomotor impairment; it also has a low potential for abuse and dependence and may be preferred over the benzodiazepines for these reasons.

Side Effects
Common side effects include: sleepiness, confusion, trouble with memory, poor coordination, dry mouth, problem with vision, and weight gain.Potentially serious side effects include angioedema, drug misuse, and an increased suicide risk.

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