Pharmaceutical Raw Materials Anti-HIV Agents Lopinavir/Ritonavir HIV Protease Inhibitors
Our factory capacity: 100kg/month
Other name: (2S)-N-[(2R,4S,5S)-5-[[2-(2,6-Dimethylphenoxy)acetyl]amino]-4-hydroxy-1,6-diphenyl-hexan-2-yl]-3-methyl-2-(2-oxo-1,3-diazinan-1-yl)butanamide
Package: 1kg/PE bag + Aluminum bag
Lopinavir is an antiviral HIV Protease Inhibitor. Lopinavir has insufficient bioavailability alone, so it is used in therapy in combination with Ritonavir, a HIV protease inhibitor, which inhibits cytochrome P450-3A4 (CYP3A4), a liver enzyme that normally metabolizes protease inhibitors.
Lopinavir and ritonavir combination is used in the treatment of the infection caused by the human immunodeficiency virus (HIV). HIV is the virus responsible for acquired immune deficiency syndrome (AIDS). It is used to slow the progression of disease in patients infected with HIV who have advanced symptoms, early symptoms, or no symptoms at all.
Lopinavir and ritonavir combination will not cure or prevent HIV infection or AIDS. It helps keep HIV from reproducing and appears to slow down the destruction of the immune system. This may help delay the development of problems usually related to AIDS or HIV disease. Lopinavir and ritonavir combination will not keep you from spreading HIV to other people. People who receive this medicine may continue to have other problems usually related to AIDS or HIV disease.
Specification Sheet (COA):
||White to light yellow color powder
|Identification by HPLC
||The retention time of the test sample corresponds to that of the reference standard
||130degree to 135degree
||131.5degree -134.2 degree
|Chromatographic purity (by HPLC, Area %)
Lopinavir (ABT-378) is an antiretroviral of the protease inhibitor class. It is used against HIV infections as a fixed-dose combination with another protease inhibitor, ritonavir, under the trade names Kaletra (high-income countries) and Aluvia (low-income countries). It was first approved by the FDA on 15 September 2000
Lopinavir combination of ritonavir
The combination of lopinavir and ritonavir is used with other medications to treat human immunodeficiency virus (HIV) infection. Lopinavir and ritonavir are in a class of medications called protease inhibitors. They work by decreasing the amount of HIV in the blood. When lopinavir and ritonavir are taken together, ritonavir also helps to increase the amount of lopinavir in the body so that the medication will have a greater effect. Although lopinavir and ritonavir will not cure HIV, these medications may decrease your chance of developing acquired immunodeficiency syndrome (AIDS) and HIV-related illnesses such as serious infections or cancer. Taking these medications along with practicing safer sex and making other life-style changes may decrease the risk of transmitting the HIV virus to other people.
Anti-HIV Agents; HIV Protease Inhibitors
The fixed combination of lopinavir and ritonavir (lopinavir/ritonavir) is used in conjunction with other antiretroviral agents for the treatment of human immunodeficiency virus type 1 (HIV-1) infection in adults, adolescents, and pediatric patients 14 days of age and older. Lopinavir/ritonavir is used in patients who are antiretroviral naive (have not previously received antiretroviral therapy) or antiretroviral experienced (received prior antiretroviral therapy).
Drug and Medication Information
Indicated in combination with other antiretroviral agents for the treatment of HIV-infection.
Lopinavir is an antiretroviral protease inhibitor used in combination with ritonavir in the therapy and prevention of human immunodeficiency virus (HIV) infection and the acquired immunodeficiency syndrome (AIDS). Lopinavir can cause transient and usually asymptomatic elevations in serum aminotransferase levels and, rarely, clinically apparent, acute liver injury. In HBV or HCV coinfected patients,highly active antiretroviral therapy with lopinavir may result of an exacerbation of the underlying chronic hepatitis Bor C
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Pharmaceutical Raw Materials Anti-HIV Agents Lopinavir/Ritonavir HIV Protease Images