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Pharmaceutical Raw Materials Anti-Paining 99.6% Purity Prilocaine/Propitocaine

  • Pharmaceutical Raw Materials Anti-Paining 99.6% Purity Prilocaine/Propitocaine
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Product Description

Pharmaceutical Raw Materials Anti-Paining 99.6% Purity Prilocaine/Propitocaine Hydrochloride

Long Acting Anesthetic Drug Raw Powder Prilocaine Base CAS 721-50-6

Product Name: Prilocaine
Synonyms: Prilocaine base
Prilocaine CAS: 721-50-6
Prilocaine MF: C13H20N2O
Prilocaine MW: 220.31
Prilocaine EINECS: 211-957-0
Prilocaine Appearance: Almost white powder
Quality standard: USP37
Purity: 99.67%
Melting point: 36~39°C
Solubility: Very soluble in alcohol and in acetone; slightly soluble in water.
Shelf life: 2 years
Prilocaine Product Categories: Active Pharmaceutical Ingredients; Inhibitors
Prilocaine Usage: It is a kind of local anesthetic drug. The product has better efficacy than procaine and the local anesthesia intensity and speed being similar as lidocaine but with longer duration time and less toxicity as well as smaller accumulation effect. It is suitable for epidural anesthesia, conduction anesthesia and infiltration anesthesia.

2, Prilocaine Applications:

Prilocaine is a local anesthetic of the amino amide type. In its injectable form, it is often used in dentistry. It is also often combined with lidocaine as a topical preparation for dermal anesthesia (lidocaine/prilocaine or EMLA), for treatment of conditions like paresthesia. As it has low cardiac toxicity, it is commonly used for intravenous regional anaesthesia (IVRA).

Prilocaine topical is a local anesthetic (numbing medication). It works by blocking nerve signals in your body.
Prilocaine topical is used to numb the skin, or surfaces of the penis or vagina, in preparation for a medical procedure or to lessen the pain of inserting a medical instrument such as a tube or speculum.
Prilocaine belongs to amide local anesthetic drug with its anesthesia intensity and speed being similar as lidocaine but with a longer duration period and weaker effect on vasodilation. It has a lower toxicity than lidocaine. It is clinically for local anesthesia, especially suitable for treating patients who are not allowed to use adrenaline.

[Pharmacological] its 3% solution has a similar local anesthesia efficacy as the anesthesia drug of 2% lidocaine together with . It has a slow onset time which lasts about 6~7min and the duration time of about 1.5~2h. It has a strong penetration capability through mucous membranes. has a slightly prolonged duration of action. PPB is 55% and T1/2 of about 1.5h. It is subject to liver metabolism with its metabolites nitroso toluidine being able to oxidize hemoglobin to form methemoglobin. It can be transported to the fetus through the placenta.

[Adverse reactions] once the usage amount exceeds 600mg, methaemoglobinaemia can occur with cyanosis, tachycardia, headache, dizziness and weakness occurring.
[Note] patients of anemia, congenital or acquired methaemoglobinaemia, respiratory failure or heart failure and hypoxic patients should be disabled. It is forbidden for applied to obstetric anesthesia.

[Usage and dosage]

Infiltration anesthesia: 0.5% to 1% solution with the duration of action of 1 to 1.5 hours.
Nerve blocking anesthesia: use 1% to 2% solution with the duration of action being 2-3 hours.
Epidural anesthesia: use10 to 30 mL of 1.5%~1% solution with the duration of action of 2.5 to 3.5 hours. Use a maximum dose of 600 mg.


Tests Results Specifications
Description Almost white powder White or almost white powder
Solubility Complies Very soluble in alcohol and in acetone; slightly soluble in water.
Identification Complies By IR, to match with the working standard
Melting point 37.5~38.9°C 36~39°C
Water 0.03% ≤0.5%
Residue on ignition 0.05% ≤0.1%
Related compound A Not detected ≤0.01%
Related compounds Complies not more than 0.2% of any individual impurity
Complies not more than one impurity exceeds 0.1%
0.13% not more than 0.5% of total impurities
Residual solvents Not detected Dichloromethane Not more than0.06%
Not detected Ethanol Not more than0.5%
0.04% Isopropyl ether Not more than0.5%
Assay 99.67% ≥99.0% (on the anhydrous basis)
Conclusion: Conforms to USP37 standard.

Surface Anesthesia Powder:
Benzocaine (CAS:94-09-7)
Tetracaine Hydrochloride (CAS:136-47-0)
Tetracaine (CAS.94-24-6)
Procaine Hydrochloride (CAS:51-05-8)
Lidocaine Hydrochloride (CAS:73-78-9)
Baclofen (CAS:1134-47-0)
Fluticasone Propionate(80474-14-2)
Gabapentin Hydrochloride(CAS.60142-96-3)
Ropivacaine Mesylate(CAS.854056-07-8)
Articaine Hydrochloride(CAS.23964-57-0)
Benzocaine Hydrochloride(CAS.23239-88-5)
Propitocaine Hydrochloride(CAS.1786-81-8)
Proparacaine Hydrochloride(CAS.5875-06-9)
Ropivacaine Hydrochloride(CAS.132112-35-7)
Pramoxine Hydrochloride(CAS.637-58-1)
Dibucaine Hydrochloride(CAS.61-12-1)
Levobupivacaine Hydrochloride(CAS.27262-48-2)
Product name Prilocaine/Propitocaine Hydrochloride MFG. Date 2016-08-30
Package 1kg/bag Batch number FH2016-08-30
Testing Date 2016-08-30 Exp Date 2018-08-30
Standard USP36 Quantity 800kg
Cas No. 1786-81-8 EINECS 217-244-0
Molecular Formula Cl3H20N2O·HCl Molecular Weight 256.7716
Function Main functions are as follows:
1. Local anesthetic.
Applications Main applications are as follows:
The material for Local anesthetic.
Items Tested Specification Result
Characters White or almost white crystalline powder Confirms
Melting Point 166ºC-169ºC 166.5ºC-168.5ºC
Solubility Freely soluble in water and in alcohol Confirms
Assay (HPLC) 99.0--101.0% (calculated on the dried basis) 99.6%
Loss on Drying Not more than 0.3% 0.16%
Related substances Not more than 1.0% 0.11%
Acetone Not more than 5000ppm conforms
Ethanol Not more than 5000ppm conforms
Sulphated ash Not more than 0.15% conforms
Heavy Metal Not more than 0.001% <0.001%
Conclusion Conforms USP36

Pharmaceutical Raw Materials Anti-Paining 99.6% Purity Prilocaine/Propitocaine Images


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