Pharmaceutical Raw Materials Sarms Powder CAS 317318-84-6 Gw-0742 Gw610742
99% Highest Quality Sarms Powder CAS 317318-84-6 Gw-0742 / Gw610742
Quick Detail :
Alias : Cardarine
CAS : 317318-70-0
Assay : > 99%
MF : C21H18F3NO3S2
MW : 453.5
MP : 134-136°C
Appearance : White powder
Product Categories : Selective Androgen Receptor ; Intermediates & Fine Chemicals ; Pharmaceuticals ; Sulfur & Selenium Compounds ; kl ; Inhibitor
Usage : It had been investigated as a potential treatment for obesity , diabetes , dyslipidemia and cardiovascular disease . GW501516 could be used by athletes as an ergogenic performance enhancing drug .
GW501516 ( also known as GW-501 ,516 , GW1516 , GSK-516 and on the black market as Endurobol ) is a PPARδ receptor agonist that was invented in a collaboration between Ligand Pharmaceuticals and GlaxoSmithKline in the 1990s , was entered into clinical development as a drug candidate for metabolic diseases and cardiovascular diseases , and was abandoned in 2007 because animal testing showed that the drug caused cancer to develop rapidly in several organs .
In 2007 research was published showing that high doses of GW501516 given to mice dramatically improved their physical performance ; the work was widely discussed in popular media , and led to a black market for the drug candidate and to its abuse by athletes as a doping agent . The World Anti-Doping Agency ( WADA ) developed a test for GW501516 and other related chemicals and added them to the prohibited list in 2009 ; it has issued additional warnings to athletes that GW501516 is not safe .
How it works :
ENDUROBOL is a selective agonist ( activator ) of the PPARδ receptor . It displays high affinity ( Ki = 1 nM ) and potency ( EC50 = 1 nM ) for PPARδ with > 1000 fold selectivity over PPARα and PPARγ .
It activates AMP-activated protein kinase and stimulates glucose uptake in skeletal muscle tissue , and GW 501516 has been demonstrated to reverse metabolic abnormalities in obese men with pre-diabetic metabolic syndrome , most likely by stimulating fatty acid oxidation . It has been proposed as a potential treatment for obesity and related conditions , especially when used in conjunction with a synergistic compound AICAR , as the combination has been shown to significantly increase exercise endurance in human .
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