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USP Pharmaceutical Raw Materials Trimetazidine Hcl Trimetazidine Dihydrochloride

  • USP Pharmaceutical Raw Materials Trimetazidine Hcl Trimetazidine Dihydrochloride
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Product Description

Pharmaceutical Raw Materials Trimetazidine Hcl Trimetazidine Dihydrochloride

Product name: Trimetazidine Dihydrochloride
CAS: 13171-25-0
Molecular formula: C14H24Cl2N2O3
Purity: 99% min
Appearance: White powder
Usage: Antineoplastic Agents,
Packing: 25kg/drum
Delivery: Within one week after payment done.

Melting point 231-235 °C(lit.)
storage temp. Refrigerator
Merck 14,9705

Trimetazidine Dihydrochloride / Citanest CAS 13171-25-0 High Quality Pharmaceutical Intermediate

Quick detail;
English name: Trimetazidine dihydrochloride
Chinese Name: Hydrochloride Trimetazidine
MF: C14H24Cl2N2O3
MW: 339.26
CAS: 13171-25-0
EINECS No.: Trimetazidine dihydrochloride 13171-25-0
Place of Origin: China (Mainland)
Type: Anesthetic Agents, Anti-Allergic Agents, Antibiotic and Antimicrobial Agents, Antidote,
Grade Standard: Cosmetic Grade, Feed Grade, Food Grade, Medicine Grade,
Usage: Animal Pharmaceuticals
Brand Name: Health
Purity: 99%
Form: White Powder


Item Specification
Specific rotation +39.5 to +41.5°
State of solution(transmittance) Clear 98.0% min.
Chloride[cl] 0.020% max.
Ammonium [NH4] 0.02% max.
Sulfate[SO4] 0.020% max
Iron[Fe] 10ppm max.
Heavy metals [Pb] 10ppm max
Arsenic[As2O3] 1ppm max
Other amino acids Chromatographically not detectable
Loss on drying 0.20% max.
Residue on ignition[sulfated] 0.10% max.
Assay 99.0% min

Trimetazidine dihydrochloride

Basic information:

Product Name: Trimetazidine dihydrochloride
Synonyms: 1-(2,3,4-TRIMETHOXYBENZYL)PIPERAZINE DIHYDROCHLORIDE;TRIMETAZIDINE DI HCL;TRIMETAZIDINE DIHYDROCHLORIDE;TRIMETAZIDINE HYDROCHLORIDE;TRIMETAZIDINE 2HCL;1-((2,3,4-trimethoxyphenyl)methyl)-piperazindihydrochloride;1-(2,3,4-trimethoxybenzyl)-piperazindihydrochloride;kyurinett
Trimetazidine dihydrochloride CAS: 13171-25-0
Trimetazidine dihydrochloride MF: C14H24Cl2N2O3
Trimetazidine dihydrochloride MW: 339.26
Trimetazidine dihydrochloride EINECS: 236-117-0
Trimetazidine dihydrochloride Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Building Blocks;C14 to C15;Chemical Synthesis;Heterocyclic Building Blocks;Piperazines
Mol File: 13171-25-0.mol

Chemical Properties:
MP 231-235 °C(lit.)
storage temp. Refrigerator
Merck 14,9705
CAS DataBase Reference 13171-25-0(CAS DataBase Reference)

Safety Information:

Hazard Codes Xn,Xi
Risk Statements 22-36/37/38
Safety Statements 26-36
WGK Germany 3
RTECS TM2976100
HazardClass IRRITANT

Usage And Synthesis:

Usage Coronary vasodilator. Antianginal

Product List of female hormone:

Product List of female hormone
Ethisterone CAS NO: 434-03-7
Norethisterone CAS NO. 68-22-4
Ethinylestradiol CAS NO: 57-63-6
Ethynodiol diacetate CAS: 297-76-7
Chlormadinone acetate CAS: 302-22-7
Estradiol CAS: 50-28-2
Estradiol Cypionate CAS: 313-06-4
Estradiol enantate CAS: 4956-37-0
Estradiol valerate CAS: 979-32-8
Estradiol Benzoatae CAS: 50-50-0
Estrone CAS NO: 53-16-7
Estriol CAS: 50-27-1
Norethisterone (Acetate) CAS: 68-22-4
Norethisterone enanthate CAS No.: 3836-23-5
  CAS: 968-93-4
Eplerenone CAS NO.: 107724-20-9
  CAS NO: 976-71-6
Formestane CAS NO: 566-48-3
Drospirenone CAS NO: 67392-87-4
Algestone acetophenide CAS: 24356-94-3
Dehydronandrolon CAS: 2590-41-2
Progesterone CAS: 57-83-0
Pregnenolone CAS: 145-13-1
Progesterone Carboxylic Acid CAS: 302-97-6
Progesterone Carboxylic Acid Methyl Ester CAS: 110988-79-9
Allylestrenol CAS: 432-60-0
Melengestrol acetate CAS: 2919-66-6

Mechanism of Action
Trimetazidine inhibits beta-oxidation of fatty acids by blocking long-chain 3-ketoacyl-CoA thiolase,which enhances glucose oxidation.In an ischaemic cell,energy obtained during glucose oxidation requires less oxygen consumption than in the beta-oxidation process.Potentiation of glucose oxidation optimizes cellular energy processes,thereby maintaining proper energy metabolism during ischaemia.By preserving energy metabolism in cells exposed to hypoxia or ischaemia,trimetazidine prevents a decrease in intracellular ATP levels,thereby ensuring the proper functioning of ionic pumps and transmembrane sodium-potassium flow whilst maintaining cellular homeostasis.

Medical Uses
Trimetazidine is usually prescribed as a long-term treatment of angina pectoris,and in some countries (including France) for tinnitus and dizziness.It is taken twice a day.In 2012 European Medicines Agency (EMA) finished a review of benefits and risks of trimetazidine and recommended restricting use of trimetazidine-containing medicines just as an additional treatment of angina pectoris in case of inadequate control by or intolerance to first-line antianginal therapies.

Controlled studies in angina patients have shown that trimetazidine increases coronary flow reserve,thereby delaying the onset of ischemia associated with exercise,limits rapid swings in blood pressure without any significant variations in heart rate,significantly decreases the frequency of angina attacks,and leads to a significant decrease in the use of nitrates.

It improves left ventricular function in diabetic patients with coronary heart disease.Recently,it has been shown to be effective in patients with heart failure of different etiologies.



USP Pharmaceutical Raw Materials Trimetazidine Hcl Trimetazidine Dihydrochloride Images


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