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HONGKONG XINCHENG GONGCHUANG TECHNOLOGY CO., LTD.

HONGKONG XINCHENG GONGCHUANG TECHNOLOGY CO., LTD.

Home > Products > Pharmaceutical Raw Materials > Pharmaceutical Raw Materials AntiEmetic Domperidone Motilium Powder
 

Pharmaceutical Raw Materials AntiEmetic Domperidone Motilium Powder

Place of Origin:
China
Brand Name:
GONGCHUANG
Certification:
ISO9001,USP,KOSHER,etc
Model Number:

SARM

Min.Order Quantity:
10gram
Price:
negotiable
Packaging Details:
25k/Drum
Delivery Time:
arrange package within 2working days after payment
Payment Terms:
T/T, Western Union, MoneyGram,bitcoin
Supply Ability:
500kg+ each week
Contact Now
 

Product Description

Pharmaceutical Raw Materials AntiEmetic Domperidone Motilium Powder

Product name:Domperidone
Other name:Motilium
Domperidone CAS#:57808-66-9
Domperidone EINECS#:260-968-7
Domperidone Molecular formula:C22H24ClN5O2
Domperidone M W:425.91
Domperidone Purity:99%min
Domperidone Appearance: White to off-white crystalline powder

Domperidone acts as a peripherally-selective antagonist of the dopamine D2 and D3 receptors, to relieve nausea and vomiting; to increase the transit of food through the stomach, to increase lactation (breast milk production) by release of prolactin.

We supply high quality of the raw material of Domperidone, as a kind of powder. Puhopharma specializes in controling the quality and reducing the impurities of Domperidone powder. Our Domperidone powder is with the best quality and the most competitive price in China.
It reachs EP7.



COA:

Items Standard Results
Appearance White or almost white powder Conforms

Identification
A.Thin-layer chromatography
B. IR spectrophotometry

Rf value of the principal spot observed in the chromatogram of test solution corresponds to that of the pricipal spot observed in the chromatogram of standard solution
IR spectrum of omeprazole sample corresponds to that of omeprazole RS.

Conforms

Conforms
Completeness of solution Clear Conforms
Color of solution The absorbance at 440 nm is not greater than 0.10 0.01
Loss on drying ≤0.5% 0.03%
Residue on ignition ≤0.1% 0.09%
Heavy metals 0.002% <0.002%
Residual solvents
Methylene chloride
Methanol
Acetone
≤600ppm
≤3000ppm
≤5000ppm
76ppm
164ppm
130ppm
Chromatographic purity
Any individual impurity
Total impurities
≤0.3%
≤1.0%
0.04%
0.11%
Microbial limits
Bacteria
Total molds and yeasts
Controlled bacteria
≤500 CFU/g
≤50 CFU/g
Absence
<10 CFU/g
<10 CFU/g
Undetectable
Assay 98.0%-102.0% 100.9%
Partical size ≥85%(≤15um) 96.1%
Conclusion Conforming to USP 36 and in-house requirements. .
 

Anti - Emetic Pharmaceutical Anabolic Steroid Powder 57808-66-9 Domperidone Motilium
Product Details:

Place of Origin China
Certification ISO9001
Payment & Shipping Terms  
Minimum Order Quantity Negotiation
Price Negotiation
Packaging Details Disguised
Delivery Time 5-8 work days
Payment Terms Western Union, MoneyGram, T/T, Bitcoin
Supply Ability 1000kg a week
Domperidone CAS 57808-66-9
MW 425.91
MSDS Avaiable
MF C22H24ClN5O2
Sample Avaiable
Category API
Min order 10grams
Quality standard USP
Place of Origin China
Appearance Domperidone is a selective inhibitor of the peripheral D2DR. The antidopaminergic effects of Domperidone have been correlated to antiemetic and gastroprokinetic action.


Description

1). Domperidone (INN, USAN, BAN, JAN) (trade names Motilium, Motillium, Motinorm Costi, Nomit, Brulium Molax) is a medication developed by Janssen Pharmaceutica that acts as a peripherally selective antagonist of the dopamine D2 and D3 receptors. It is administered orally, rectally, or intravenously. Domperidone is given in order to relieve nausea and vomiting;

2). to increase the transit of food through the stomach (as a prokinetic agent through increase in gastrointestinal peristalsis); and to increase lactation (breast milk production) by release of prolactin. It is also used in the scientific study of the way dopamine (an important neurotransmitter and hormone) acts in the body.

3). Domperidone is available in the form of tablets, orally disintegrating tablets (based on Zydis technology),suspension and suppositories. Domperidone is a kind of potent peripheral dopamine receptor antagonist with anti-vomiting and gastro-kinetic effects.

4). It can affect the gastrointestinal motility to make the motility and tension of upper gastrointestinal tract return to normal and promote gastric emptying, enhancing the antral and duodenal motility, and coordinating the pyloric contraction. It can be used for the treatment of dyspepsia, and the nausea and vomiting induced by functional, organic, infection, dietary, radiation therapy or drug therapy.

5). Because it almost has no inhibitory effect on dopamine receptor, there are no psychiatric and neurological side effects. And it can be used for treating the nausea caused by treating the Parkinsons disease through taking dopamine agonists. It can be used as anticholinergic antispasmodics.

Uses

The uses or indications of domperidone vary between nations. For instance, in Italy it is used in the treatment of gastroesophageal reflux disease and in Canada, the drug is indicated in upper gastrointestinal motility disorders and to prevent gastrointestinal symptoms associated with the use of dopamine agonist antiparkinsonian agents. A novel peripheral dopamine receptor antagonist that does not cross the blood-brain barrier; anti-emetic. Domperidone(Motilium) is a dopamine blocker and an antidopaminergic reagent.

Application

1). Domperidone is a kind of phenyl imidazole compounds with a strong role in promoting gastric motility and antiemetic effect. It can strengthen the tension of the sphincter of the lower part of the esophagus, preventing the stomach - esophageal reflux, enhancing the gastric motility, promoting the gastric emptying, coordinating the stomach and duodenal motility, suppressing nausea, vomiting, and effectively preventing the bile reflux without affecting the secretion of gastric juice.

2). This product is a kind of peripheral dopamine receptor antagonists which can directly block the gastrointestinal dopamine receptors and exhibit the stimulating effect of gastric motility. It can enhance the esophageal peristalsis and the tension of esophageal sphincter. Because of its poor penetration through the blood brain barrier, it has almost no antagonism against the dopamine receptor of the brain, and therefore can excluding the side effects of the spirit and the central nervous system.

3). A novel peripheral dopamine receptor antagonist that does not cross the blood-brain barrier; anti-emetic. Domperidone(Motilium) is a dopamine blocker and an antidopaminergic reagent. For management of dyspepsia, heartburn, epigastric pain, nausea, and vomiting.

Packaging & Delivery:

We have sufficient stock and can delivery promptly at the very day when receive the payment. The Sophisticated and professional logistic agent will coordinate with us to provide our customers with fast delivery and secure shipping. We also have well- trained and disciplined packing team. It will be arranged in fast and discreet shipment for customs pass Guaranteed. At the same time, packing pictures and tacking code will be provided within 12 hours after receiving the payment. Updated tracking information will be provided every other day. We pay much attention to after- sale service: Any questions or problems after receiving the product, please feel free to contact us. Problems would be solved immediately.

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