Chloramphenicol Pharmaceutical Raw Materials 56-75-7 99% Antibiotics Alkaloid
Chloramphenicol (chloramphenicol) is a white or colorless needle-like or flaky crystal, melting point 149.7 ~ 150.79C, soluble in methanol, ethanol, propanol and ethyl acetate, slightly soluble in ether and chloroform, insoluble in petroleum ether And benzene. Chloramphenicol is extremely stable and its aqueous solution does not fail after boiling for 5 h. The chloramphenicol molecule contains para-nitrophenyl groups, propylene glycol, and dichloroacetamide groups. Since there are two asymmetric carbon atoms in the chloramphenicol molecule, there are four optical isomers of the sterilomycin, of which only the levorotatory isomer has antibacterial activity.
chloramphenicol CAS NO.:56-75-7
chloramphenicol Molecular Formula:C11H12Cl2N2O5
chloramphenicol Molecular Weight:323.13
chloramphenicol Appearance:white powder
Grade:Pharmaceutical Grade,Industrial Grade
Chloramphenicol is an antibiotic useful for the treatment of a number of bacterial infections.This includes meningitis, plague, cholera, and typhoid fever. Its use is only recommended when safer antibiotics cannot be used. Monitoring both blood levels of the medication and blood cell levels every two days is recommended during treatment.It is available intravenously, by mouth, and as an eye ointment.
The original indication of chloramphenicol was in the treatment of typhoid, but the now almost universal presence of multiple drug-resistant Salmonella typhi has meant it is seldom used for this indication except when the organism is known to be sensitive. Chloramphenicol may be used as a second-line agent in the treatment of tetracycline-resistant cholera.
Chloramphenicol is active against the three main bacterial causes of meningitis: Neisseria meningitidis, Streptococcus pneumoniae, and Haemophilus influenzae. In the West, chloramphenicol remains the drug of choice in the treatment of meningitis in patients with severe penicillin or cephalosporin allergy and general practitioners are recommended to carry intravenous chloramphenicol in their bag. In low-income countries, the WHO recommend oily chloramphenicol as first-line to treat meningitis.
Although its use in veterinary medicine is highly restricted, chloramphenicol still has some important veterinary uses.It is currently considered the most useful treatment of chlamydial disease in koalas.The pharmacokinetics of chloramphenicol have been investigated in koalas.
|CAS register number||56-75-7|
|Molecular structure|| |
|Appearance||white or yellohreen crystal or powder|
|Package||25kg/ drum or as required|
|Usage||can be used as pharmaceutical material|
|Minimum order quantity||1kg|
|Shipping||By express courier|
|Shipping leading time||Within 12 hours after receiving the payment|
|Payment options||Western Union, MoneyGram, T/T|
antibacterial, antirickettsial, inhibits protein synthesis
Usage Chloramphenicol is unusual nitroaromatic metabolite produced by Streptomyces venezuelae, first published in 1947. Chloramphenicol is a broad spectrum antibiotic with good activity against Gram negative and anaerobic bacteria. Although restricted to ocular use, antibiotic resistance to other classes has refocused attention on this class. Chloramphenicol acts by binding to the 23S sub-unit of the 50S ribosome, inhibiting protein synthesis. Chloramphenicol has been extensively studied with over 35,000 literature citations.
Usage Broad spectrum antibiotic obtained from cultures of the soil bacterium Streptomyces venezuelae. It has a broad spectrum of activity against Gram-positive and gram-negative bacteria. Antibacterial; antirickettsial
Chloramphenicol is on the World Health Organizations List of Essential Medicines, a list of the most important medications needed in a basic health system.
The most serious adverse effect associated with chloramphenicol treatment is bone marrow toxicity, which may occur in two distinct forms: Bone marrow suppression, which is a direct toxic effect of the drug and is usually reversible, and aplastic anemia, which is idiosyncratic (rare, unpredictable, and unrelated to dose) and generally fatal.
Because of its excellent blood-brain barrier penetration (far superior to any of the cephalosporins), chloramphenicol remains the first-choice treatment for staphylococcal brain abscesses. It is also useful in the treatment of brain abscesses due to mixed organisms or when the causative organism is not known.
Use of intravenous chloramphenicol has also been associated with gray baby syndrome, a phenomenon resulting from newborn infants inability to metabolize chloramphenicol in the body. Other less serious reactions include fever, rashes, headache, and confusion. Prescription use is usually associated with monitoring of a patients complete blood count. The drug should be discontinued upon appearance of reticulocytopenia, leukopenia, thrombocytopenia, anemia, or any other abnormal blood study findings attributable to chloramphenicol.
Although unpublished, recent research suggests chloramphenicol could also be applied to frogs to prevent their widespread destruction from fungal infections. It has recently been discovered to be a life-saving cure for chytridiomycosis in amphibians.
Chloramphenicol Pharmaceutical Raw Materials 56-75-7 99% Antibiotics Alkaloid Images