Place of Origin: China
Model Number: 15663-27-1
Payment & Shipping Terms:
Minimum Order Quantity: 1kg
Packaging Details: bags or drum
Delivery Time: 3-5 days
Payment Terms:T/T, Western Union, MoneyGram
Supply Ability:200kg per mont
Product Name: Cisplatin
Appearance: Yellow Crystal Powder
Yellow Crystal Powder Cisplatin Active Pharmaceutical Ingredient CAS 15663-27-1
CAS NO. 15663-27-1
Molecular Formula C6H12N2O4Pt
Molecular Weight 371.25
Standard Assay ≥99%
Test Method HPLC
Packing 100G;500G;1Kg;25Kg(Export worthy packing)
Remark For more details,please contact us
Cisplatin is administered intravenously as short-term infusion in normal saline for treatment of solid malignancies. It is used to treat various types of cancers, including sarcomas, some carcinomas (e.g., small cell lung cancer, squamous cell carcinoma of the head and neck and ovarian cancer), lymphomas, bladder cancer, cervical cancer,and germ cell tumors.
Cisplatin is particularly effective against testicular cancer; the cure rate was improved from 10% to 85%.
In addition, cisplatin is used in Auger therapy.
Cisplatin has a number of side-effects that can limit its use:
Nephrotoxicity (kidney damage) is a major concern. The dose is reduced when the patients creatinine clearance (a measure of renal function) is reduced. Adequate hydration and diuresis is used to prevent renal damage. The nephrotoxicity of platinum-class drugs seems to be related to reactive oxygen species and in animal models can be ameliorated by free radical scavenging agents (e.g., amifostine). Nephrotoxicity is a dose-limiting side effect.
Neurotoxicity (nerve damage) can be anticipated by performing nerve conduction studies before and after treatment. Common neurological side effects of cisplatin include visual perception and hearing disorder, which can occur soon after treatment begins.
Nausea and vomiting: cisplatin is one of the most emetogenic chemotherapy agents, but this symptom is managed with prophylactic antiemetics (ondansetron, granisetron, etc.) in combination with corticosteroids. Aprepitant combined with ondansetron and dexamethasone has been shown to be better for highly emetogenic chemotherapy than just ondansetron and dexamethasone.
Ototoxicity (hearing loss): there is at present no effective treatment to prevent this side effect, which may be severe. Audiometric analysis may be necessary to assess the severity of ototoxicity. Other drugs (such as the aminoglycoside antibiotic class) may also cause ototoxicity, and the administration of this class of antibiotics in patients receiving cisplatin is generally avoided. The ototoxicity of both the aminoglycosides and cisplatin may be related to their ability to bind to melanin in the stria vascularis of the inner ear or the generation of reactive oxygen species.
Electrolyte disturbance: Cisplatin can cause hypomagnesaemia, hypokalaemia and hypocalcaemia. The hypocalcaemia seems to occur in those with low serum magnesium secondary to cisplatin, so it is not primarily due to the cisplatin.
Hemolytic anemia can be developed after several courses of cisplatin. It is suggested that an antibody reacting with a cisplatin-red-cell membrane is responsible for hemolysis
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Yellow Crystal Powder Cisplatin Active Pharmaceutical Raw Materials CAS 15663-27 Images