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Home > Products > Pharmaceutical Raw Materials > Fluoxetine HCl Pharmaceutical Raw Materials For Anti -Depression CAS 54910-89-3
 

Fluoxetine HCl Pharmaceutical Raw Materials For Anti -Depression CAS 54910-89-3

Place of Origin:
China
Brand Name:
HKYC
Certification:
ISO9001
Model Number:

API

Min.Order Quantity:
1KG
Price:
usd
Packaging Details:
25kg/drum,box,bag ,etc
Delivery Time:
1-3 working days
Payment Terms:
Western Union, MoneyGram, T/T
Supply Ability:
500kg per week
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Product Description

Fluoxetine HCl Pharmaceutical Raw Materials For Anti -Depression CAS 54910-89-3

Description

Products Name: Fluoxetine hydrochloride

Synonyms : Methyl[3-phenyl-3-[4-(trifluoromethyl)phenoxy]propyl]amine hydrochloride; N-Methyl-gama-[4-(trifluoromethyl)

CAS No: 59333-67-4;56296-78-7

EINECS No: 260-101-2

Molecular Formula: C23H23NO4

Molecular Weight: 377.433

Introduction

Fluoxetine was shown to be effective for depression in six-week-long double-blind controlled trials, where it also alleviated anxiety and improved sleep. Fluoxetine was better than placebo for the prevention of depression recurrence when the patients, who originally responded to fluoxetine, were treated for a further 38 weeks. Efficacy of fluoxetine for geriatric, as well as pediatric, depression was also demonstrated in placebo-controlled trials.

Research suggests that a significant part of the resistance to the SSRIs paroxetine (Paxil) and citalopram(Celexa) can be explained by the genetic variation of Pgp transporter. Paroxetine and citalopram, which are Pgp substrates, are actively transported from the brain by this protein. Fluoxetine is not a substrate of Pgp, and thus a switch from paroxetine or citalopram to fluoxetine may be beneficial to the nonresponders.

Function

Fluoxetine is frequently used to treat major depression, obsessive compulsive disorder, bulimia nervosa,panic disorder, body dysmorphic disorder, premenstrual dysphoric disorder, and trichotillomania. Caution should be taken when using any SSRI for bipolar disorder as this can increase the likelihood of mania; however, fluoxetine can be used with an antipsychotic (such as quetiapine) for bipolar. It has also been used for cataplexy, obesity, and alcohol dependence,as well as binge eating disorder.

COA

Appearance White crystal White crystal

Identification

A:Infrared absorption

B:Retention of time

A: Positive

B: Positive

A: Complies

B: Complies

Assay 98.0~101.5% 100.20%
Optical rotation -0.05~+0.05 +0.01
Total impurity ≤0.5% Complies%
3-methylaminol-l-phenylpropan-l-ol ≤0.25% 0.05%
N-methyl-3-phenylpropyl-l-amine ≤0.25% 0.05%
N-methyl-3-phenyl-3-(trifluoromet hylphenoxy) propyl-l-amine ≤0.15% 0.03%
Other impurity ≤0.10% Complies
Organic volatile impurity Complies Complies
Sulphated ash ≤0.1% 0.02%
Water ≤0.5% 0.20%
pH 4.5~6.5 5.70
Heavy metals ≤10ppm Complies
Solubility Colorless clear Colorless clear
TVC ≤10 cfn/g Complies
Mould and yeast ≤10 cfn/g Complies
Conclusion: comply with the USP30/BP2002

Information of Fluoxetine :

Name:Fluoxetine

Chemical name: (RS) -N-methyl-3-phenyl-3-[4- (trifluoromethyl) pheno

Molecular Formula: C17H18F3NO

CAS Registry Number: 54910-89-3

Synonyms: Adofen;Fluval;Fluctin;Foxetin;Reneuron;Fluoxeren;fluoxetina;FLUOXETINE

Chemical Properties

Molecular Weight: 309.3 g/mol (345.8 for HCl)

Character: used its hydrochloride, melting point is 179 °C -182 °C.

Product Introduction

.

Fluoxetine is used for the treatment of major depressive disorder (including pediatric depression), obsessive-compulsive disorder (in both adults and children), bulimia nervosa, panic disorder, and premenstrual dysphoric disorder. In addition, it is used to treat trichotillomania if cognitive behaviour therapy has been unsuccessful.

Puhopharma specializes in controling the quality and reducing the impurities of Fluoxetine powder. Our Fluoxetine powder is with the best quality and the most competitive price in China.

Main Function:

Fluoxetine is frequently used to treat major depression, obsessive compulsive disorder, bulimia nervosa,panic disorder, body dysmorphic disorder, premenstrual dysphoric disorder, and trichotillomania. Caution should be taken when using any SSRI for bipolar disorder as this can increase the likelihood of mania; however, fluoxetine can be used with an antipsychotic (such as quetiapine) for bipolar. It has also been used for cataplexy, obesity, and alcohol dependence,as well as binge eating disorder.

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