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Pharmaceutical Intermediates Etretin Acitretin For Antipsoriatic CAS 55079-83-9

  • Pharmaceutical Intermediates Etretin Acitretin For Antipsoriatic CAS 55079-83-9
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Pharmaceutical Raw Materials

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Product Description

Pharmaceutical Intermediates Etretin Acitretin For Antipsoriatic CAS 55079-83-9



Acitretin Basic Details


Product Name Acitretin
Alias etretin
CAS 55079-83-9
MF C21H26O3
MW 326.43
EINECS 259-474-4
Purity 99.50%
Grade Pharmaceutical Grade
Appearance Yellow or greenish-yellow crystalline powder
Brand Nmae HKYC
Standard EP6.0
Stock Mass Stock
Packing Methods designed disguised packing ways, 100% pass custom guarantee
Delivery time within 18 hours after payment confirmed
Payment T/T, Western Union,Money Gram , Bitcoin
Usage A synthetic retinoid which is the major metabolite of etretinate.


Acitretin Descrption


1. Acitretin is a second generation retinoid. It is taken orally, and is typically used for psoriasis. It is a metabolite of etretinate, which was used prior to the introduction of acitretin.


Etretinate was discontinued because it had a narrow therapeutic index as well as a long elimination half-life (t1/2=120 days), making dosing difficult. In contrast, acitretins half-life is approximately 2 days.


Because acitretin can be reverse metabolised into etretinate which has a long half life, women must avoid becoming pregnant for at least 2 years after discontinuing acitretin. Therefore, etretinate is generally not recommended for women of child bearing age with a risk of becoming pregnant.


2. Acitretin is the least toxic systemic treatment for psoriasis. It is an oral retinoid of choice used in the treatment of severe resistant psoriasis. It binds to nuclear receptors that regulate gene transcription. They induce keratinocyte differentiation and reduce epidermal hyperplasia. Acitretin is readily absorbed and widely distributed after oral administration. A therapeutic effect occurs after 2 to 4 weeks or longer. If a patient has received the medication, he/she is advised against giving blood for at least 3 years due to the risk of birth defects.


Acitretin Application


For the treatment of psoriasis (severe refractory cases, including erythrodermic andgeneralized pustular), severe refractory oral lichen planus, keratosis refractory severeintractable disorders (such as ichthyosis-like skin disease, congenital ichthyosis-likeerythroderma, lamellar ichthyosis and other ichthyosis), follicular keratosis, palmoplantarkeratosis, pityriasis rubra pilaris, palmoplantar pus fibromatosis.


Acitretinis widely applied in pharmaceutical field, mainly used for the cure of dermatonosus like acne, ichthyosis and psoriasis abnormal, etc.


For skin keratinocytes-resistant drugs and cell-induced differentation drug.


Side effect


Acitretin is noted for the possibility of severe birth defects and should not be used by pregnant women or women planning to get pregnant within 3 years following the use of acitretin. Sexually active women of childbearing age who use acitretin should also use at least 2 forms of birth control concurrently. Men and women who use it shouldnot donate blood for 3 years after using it, because of the possibility that the blood might be used in a pregnant patient and cause birth defects. In addition, it may cause nausea, headache, itching, dry, red or flaky skin, dry or red eyes, dry or chapped lips, swollen lips, dry mouth, thirst, cystitis acne or hair loss.



Acitretin Specification


Items of analysis Specification Results
Appearence Yellow or greenish-yellow crystalline powder yellow crystalline powder
Identification A) The specific absorbance at the max is 1350 to 1475 Conforms
First Identification B B) Sample IR spectrum must match with that of standard Conforms
Second Identification A C C) Sample HPLC spectrum must match with that of standard Conforms
Solubility Practically insoluble in water, sparingly soluble in tetrahydrofuran. Slightly soluble in acetone and in ethanol(96 percent). Very slightly soluble in cyclohexane. Conforms
Loss on drying ≤0.5% 0.30%
Sulfated ash ≤0.1% 0.05%
Heavy metals ≤0.002% < 0.002%
Palladium ≤0.001% <0.001%
Related substances Impurity A ≤0.3% 0.18%
Related substances Impurity B ≤0.3% 0.16%
Total impurity ≤1.0% 0.40%
Assay (anhydrous) 98.0%-102.0% 99.90%
Conclusion The results can conform to EP6.0 Standard


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6.Delivery Time: US :3-5 days, UK: 4-7 days, Canada: 3-7 days, Europe: 6-10 days



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