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HONGKONG XINCHENG GONGCHUANG TECHNOLOGY CO., LTD.

HONGKONG XINCHENG GONGCHUANG TECHNOLOGY CO., LTD.

Home > Products > Pharmaceutical Raw Materials > Pharmaceutical Intermediates Etretin Acitretin For Antipsoriatic CAS 55079-83-9
 

Pharmaceutical Intermediates Etretin Acitretin For Antipsoriatic CAS 55079-83-9

  • Pharmaceutical Intermediates Etretin Acitretin For Antipsoriatic CAS 55079-83-9
Place of Origin:
HUBEI,CHINA
Brand Name:
HKYC
Certification:
ISO 9000, SGS
Model Number:

Pharmaceutical Raw Materials

Min.Order Quantity:
10grams
Price:
negotiable(best offer will be provided)
Packaging Details:
designed disguised packing ways, 100% pass custom guarantee)
Delivery Time:
within 24hours after payment confirm
Payment Terms:
MoneyGram, Western Union, T/T, Bitcoin
Supply Ability:
1000Kg per Month
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Product Description

Pharmaceutical Intermediates Etretin Acitretin For Antipsoriatic CAS 55079-83-9

 

 

Acitretin Basic Details

 

Product Name Acitretin
Alias etretin
CAS 55079-83-9
MF C21H26O3
MW 326.43
EINECS 259-474-4
Purity 99.50%
Grade Pharmaceutical Grade
Appearance Yellow or greenish-yellow crystalline powder
Brand Nmae HKYC
Standard EP6.0
Stock Mass Stock
Packing Methods designed disguised packing ways, 100% pass custom guarantee
Delivery time within 18 hours after payment confirmed
Payment T/T, Western Union,Money Gram , Bitcoin
Usage A synthetic retinoid which is the major metabolite of etretinate.

 

Acitretin Descrption

 

1. Acitretin is a second generation retinoid. It is taken orally, and is typically used for psoriasis. It is a metabolite of etretinate, which was used prior to the introduction of acitretin.

 

Etretinate was discontinued because it had a narrow therapeutic index as well as a long elimination half-life (t1/2=120 days), making dosing difficult. In contrast, acitretins half-life is approximately 2 days.

 

Because acitretin can be reverse metabolised into etretinate which has a long half life, women must avoid becoming pregnant for at least 2 years after discontinuing acitretin. Therefore, etretinate is generally not recommended for women of child bearing age with a risk of becoming pregnant.

 

2. Acitretin is the least toxic systemic treatment for psoriasis. It is an oral retinoid of choice used in the treatment of severe resistant psoriasis. It binds to nuclear receptors that regulate gene transcription. They induce keratinocyte differentiation and reduce epidermal hyperplasia. Acitretin is readily absorbed and widely distributed after oral administration. A therapeutic effect occurs after 2 to 4 weeks or longer. If a patient has received the medication, he/she is advised against giving blood for at least 3 years due to the risk of birth defects.

 

Acitretin Application

 

For the treatment of psoriasis (severe refractory cases, including erythrodermic andgeneralized pustular), severe refractory oral lichen planus, keratosis refractory severeintractable disorders (such as ichthyosis-like skin disease, congenital ichthyosis-likeerythroderma, lamellar ichthyosis and other ichthyosis), follicular keratosis, palmoplantarkeratosis, pityriasis rubra pilaris, palmoplantar pus fibromatosis.

 

Acitretinis widely applied in pharmaceutical field, mainly used for the cure of dermatonosus like acne, ichthyosis and psoriasis abnormal, etc.

 

For skin keratinocytes-resistant drugs and cell-induced differentation drug.

 

Side effect

 

Acitretin is noted for the possibility of severe birth defects and should not be used by pregnant women or women planning to get pregnant within 3 years following the use of acitretin. Sexually active women of childbearing age who use acitretin should also use at least 2 forms of birth control concurrently. Men and women who use it shouldnot donate blood for 3 years after using it, because of the possibility that the blood might be used in a pregnant patient and cause birth defects. In addition, it may cause nausea, headache, itching, dry, red or flaky skin, dry or red eyes, dry or chapped lips, swollen lips, dry mouth, thirst, cystitis acne or hair loss.

 

 

Acitretin Specification

 

Items of analysis Specification Results
Appearence Yellow or greenish-yellow crystalline powder yellow crystalline powder
Identification A) The specific absorbance at the max is 1350 to 1475 Conforms
First Identification B B) Sample IR spectrum must match with that of standard Conforms
Second Identification A C C) Sample HPLC spectrum must match with that of standard Conforms
Solubility Practically insoluble in water, sparingly soluble in tetrahydrofuran. Slightly soluble in acetone and in ethanol(96 percent). Very slightly soluble in cyclohexane. Conforms
Loss on drying ≤0.5% 0.30%
Sulfated ash ≤0.1% 0.05%
Heavy metals ≤0.002% < 0.002%
Palladium ≤0.001% <0.001%
Related substances Impurity A ≤0.3% 0.18%
Related substances Impurity B ≤0.3% 0.16%
Total impurity ≤1.0% 0.40%
Assay (anhydrous) 98.0%-102.0% 99.90%
Conclusion The results can conform to EP6.0 Standard

 

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2. Parcel : Designed Discreet packing according to different countries and quantity.

 

3. Pass Custom Rate: more than 99%.

 


5. Delivery Methods: EMS, DHL, FedEx, UPS, TNT, Aramex, China/Hongkong/ Singapore/Sweden/Holland Post Mail. All with tracking code. Usual delivery time is 4-7 workdays.

6.Delivery Time: US :3-5 days, UK: 4-7 days, Canada: 3-7 days, Europe: 6-10 days

 

 

Packaging & Service:


1. Mass stock, to make sure delivery promptly every day when the payment is done.
2. Having been engaged in this field for years, we have sophisticated and professional logistics department, which can guarantee safe and speedy delivery.
3. Well-trained and disciplined packing team which is professional enough to provide you a safe package. It also avoid a lot of emergency happen during the delivery so that high customs pass is guaranteed. Unique ways to ship 10grams to 25 kilograms powders(or 100ml to 30 Liter liquids) at one time to your destination.
4. Packing pictures and tacking code are provided within 24 hours as soon as receiving the payment. Updated tracking code will be provided every other day just for you can hold a palm of your package.
5. Perfect after-sale service: Any questions or problems happened after receiving the product.

 

 

 

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