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HONGKONG XINCHENG GONGCHUANG TECHNOLOGY CO., LTD.

HONGKONG XINCHENG GONGCHUANG TECHNOLOGY CO., LTD.

Home > Products > Pharmaceutical Raw Materials > Pharma Grade Raw Powder Losartan Potassium CAS 124750-99-8 For Hypertension
 

Pharma Grade Raw Powder Losartan Potassium CAS 124750-99-8 For Hypertension

  • Pharma Grade Raw Powder Losartan Potassium CAS 124750-99-8 For Hypertension
Place of Origin:
HUBEI,CHINA
Brand Name:
HKYC
Certification:
ISO 9000, SGS
Model Number:

Gefitinib

Min.Order Quantity:
10grams
Price:
negotiable(best offer will be provided)
Packaging Details:
foil bag or as your mind
Delivery Time:
within 24hours after payment confirm
Payment Terms:
MoneyGram, Western Union, T/T, Bitcoin
Supply Ability:
1000Kg per Month
Contact Now
 

Product Description

Pharma Grade Raw Powder Losartan Potassium CAS 124750-99-8 For Hypertension

 

 

Losartan Potassium Basic Info

 

Product Name Losartan potassium
Alias Losartan, Cozaar
CAS 124750-99-8
MF C22H23ClKN6O
MW 462.01.
EINECS 200-287-4
Purity 99.50%
Grade Pharmaceutical Grade
Appearance white Crystalline Powder
Brand Nmae HKYC
Standard USP
Stock Mass Stock
Shelf Life 2years
Packing Methods foil bag or as your mind
Delivery time within 18 hours after payment confirmed
Payment T/T, Western Union,Money Gram , Bitcoin
Usage Losartan potassium is an angiotensin II receptor antagonist drug.
Losartan potassium is used to treat high blood pressure (hypertension).

 

Losartan potassium Introduction

 

1. Losartan is an angiotensin II receptor antagonist drug used mainly to treat high blood pressure (hypertension). It was the first angiotensin II antagonist to be marketed. under the trade name Cozaar, and is available in generic form.

 

2. Losartan (Cozaar) belongs to a group of drug called angiotensin II receptor antagonists. It keeps blood vessels from narrowing, which lowers blood pressure and improves blood flow.

 

Losartan is used to treat high blood pressure (hypertension). It is also used to lower the risk of stroke in certain people with heart disease.

 

3. Losartan is used to slow long-term kidney damage in people with type 2 diabetes who also have high blood pressure.

 

Losartan potassium Useage

 

As with all angiotensin II type 1 receptor (AT1) antagonists, losartan is indicated for the treatment of hypertension. It may also delay progression of diabetic nephropathy and is associated with a positive clinical outcome in that regard. It is a suitable pharmacological agent for the reduction of renal disease progression in patients with type 2 diabetes, hypertension, and microalbuminuria or proteinuria.

 

Losartan is also available as losartan, acombination drug with a low-dose thiazide dluretic to achieve an additive antihypertensive effect.

 

How Losartan potassium works

 

1. Losartan potassium,Losartan is well absorbed following oral administration and undergoes significant first-pass metabolism to produce the 5-carboxylic acid metabolite, designated as EXP3174. About 14% of an oral dosage is converted to this metabolite, which is long-acting (6 to 8 hr) and a noncompetitive antagonist at the AT1 receptor, contributing to the pharmacological effects of losartan. EXP3174 is 10-40 times more potent in blocking AT1 receptors than losartan. Losartans bioavailability is about 32%.

 

2. Losartan potassium,Metabolism is primarily by cytochrome P450 isoenzymes CYP2C9 and CYP3A4. Peak plasma concentrations of losartan and EXP3174 occur about one hour and three to four hours, respectively, after an oral dose. Both losartan and EXP3174 are more than 98% bound to plasma proteins. Losartan is excreted in the urine, and in the feces via bile, as unchanged drug and metabolites. About 4% of an oral dose is excreted unchanged in urine, and about 6% is excreted in urine as the active metabolite. The terminal elimination half lives of losartan and EXP3174 are about 1.5 to 2.5 hours and 3 to 9 hours, respectively.

 

Losartan potassium Specification

 

Items of analysis Specification Results
Characters White or off white crystalline powder off white powder
Solubility

Free soluble in water and methanol,

very slightly soluble in chloroform

Conforms
Infraed absorption Must similar to reference standard Conforms
Ultraviolet absorption Must similar to reference standard Conforms
Test for potassium Must be positive positive
Water ≤0.5% 0.20%
Heavy metals ≤10ppm <10ppm
Single impurity ≤0.2% 0.07%
Total impurity ≤0.5% 0.12%
Isopropyl alcohol ≤2000ppm 234ppm
Assay 98.5-101% 99.8%
Conclusion

Qualified

 

 

 

About US

 

Welcome to HKYC. Our company specialize in pharmaceutical raw materials, like anti-depression drug raw material , anti acne drug raw material, antibiotic raw material, Nootropics Drug raw material, Nervous System Drug raw material, Local Anaesthetic Agents, steroid hormone, sarms, peptides and pain killers etc.

 

We always willing to make a better deal for you. For regular customers we are giving great offers.

Once one become our customer, he will definitely return for another order.

 

Our mission is to provide our customer with an excellent personal service which develops long-term relationship, meeting their specific needs within budget and time frame. Ensure regulatory compliance are maximize on clients core competencies and product quality through optimized validated and controlled processes.

 

We have customer desired packing methods chosen and recommended by most of our customers.

We do pack as the customer desires the package to be packed....

 

All products are produced under GMP conditions according to Standard Operation Procedure(SOP),

not from little underground labs or black markets, so the quality is guaranteed.

 

Prices depends on your order but we always encourage new clients to place sample / small orders and check our service,

products and our communication and then gradually do your regular business with us. Of course bulk orders will enjoy discounts.

 

All products are bulk in stock, usually ship within 24-48 hours of your order being received and processed. Fast Express Delivery ,Available with UPS,FedEx,EMS,DHL,TNT and so on,

secure shipping and fast T/A. US :3-5 days, UK: 4-7 days, Canada: 3-7 days, Europe: 6-10 days

 

If you need quality products and timely delivery then you do not need to go anywhere else,

just contact us and we serve you a lot better then anyone else.

 

 

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