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Home > Products > Pharmaceutical Raw Materials > Nootropic Sleep Aid Agomelatine Melatonergic Antidepressant CAS 138112-76-2
 

Nootropic Sleep Aid Agomelatine Melatonergic Antidepressant CAS 138112-76-2

  • Nootropic Sleep Aid Agomelatine Melatonergic Antidepressant CAS 138112-76-2
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HUBEI,CHINA
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pharmaceutical Intermediates Powder

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10g
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Supply Ability:
500/month
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Product Description

 

Nootropic Sleep Aid Agomelatine Melatonergic Antidepressant CAS 138112-76-2

 

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Product Name:AGOMELATINE
Synonyms:AGOMELATINE;n-(2-(7-methoxy-1-naphthalenyl)ethyl)-acetamid;n-(2-(7-methoxy-1-naphthalenyl)ethyl)acetamide;n-(2-(7-methoxynaphth-1-yl)ethyl)acetamide;S20098,N-[2-(7-Methoxynaphth-1-yl)ethyl]acetamide;S 20098;AGOMELATIN;Acetamide, N-(2-(7-methoxy-1-naphthalenyl)ethyl)-
CAS:138112-76-2
MF:C15H17NO2
MW:243.30098
Product Categories: Aromatics Compounds;Aromatics;Neurochemicals;APIS;API;Agomelatine;Valdoxan, Melitor, Thymanax
ApplicationMelatonin drugs.
Chemical Properties:White Solid
Usage: Agomelatine is an antidepressant drug. It is classified as a norepinephrine-dopamine disinhibitor (NDDI) due to its antagonism of the 5-HT2C receptor. Activation of 5-HT2C receptors by serotonin inhibits dopamine and norepinephrine release. Antagonism of
Usage: Agomelatine is a melatoninergic agonist and selective antagonist of 5-HT2C receptors, and has been shown to be active in several animal models of depression. Agomelatine (S20098) displayed pKi values of 6.4 and 6.2 at native (porcine) and cloned, human (h)5-hydroxytryptamine (5-HT)2C receptors, respectively.

 

What is Agomelatine?
Agomelatine (BAN, rINN; trade names Valdoxan, Melitor, Thymanax) is a melatonergic antidepressant developed by the pharmaceutical company Servier. Agomelatine is marketed for the treatment of major depressive disorder, primarily for its relatively favorable side effect profile: it avoids the weight gain, sexual dysfunction, and severe withdrawal associated with the most commonly used classes of antidepressants (SSRIs, SNRIs, tricyclics), while providing similar therapeutic benefit.

Due to its distinctive mechanism of action, agomelatine is also studied for its effects on sleep regulation. Studies report various improvements in general quality of sleep metrics, as well as specific therapeutic benefits in circadian rhythm disorders.

 

How does it work?
Valdoxan tablets contain the active ingredient agomelatine, which is a type of medicine called an antidepressant. It is used to treat depression.
Agomelatine acts on the melatonin and serotonin receptors in the brain.
Melatonin is a hormone made by the pineal gland, a structure in the brain. It is normally released soon after it starts to get dark. The amount produced then increases until about four am, before dropping off again. Melatonin is linked with the control of circadian rhythms and promoting sleep. It works by acting on melatonin receptors in the brain.

Agomelatine mimics the action of melatonin and helps to re-synchronise the bodys circadian rhythms. These include mood, anxiety, appetite, body temperature and sleep/wake cycles. These circadian rhythms, particularly sleep cycles, are severely disturbed in people with depression. Agomelatines main action is to improve the onset and quality of sleep and this in turn has an antidepressant effect.

 

Agomelatine also helps to improve mood in depression by increasing noradrenaline and dopamine release in the brain. These are natural chemicals called neurotransmitters that are involved, amongst other things, in regulating mood.

 

Before taking agomelatine:

Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking agomelatine it is important that your doctor knows:

 

If you are under 18 or over 75 years of age.
If you are pregnant or breast-feeding.
If you have any problems with the way your liver works, or if you have any problems with the way your kidneys work.
If you have ever had abnormally high moods or dementia.
If you are taking any other medicines. This includes any medicines which are available to buy without a prescription, as well as herbal and complementary medicines.
If you have ever had an allergic reaction to a medicine.

 

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Supply ability:200kg/month

 

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