99% Purity Nootropic Pharmaceutical Chemicals Galanthamine Galantamine
Factory Supply CAS 1953-04-4 Galantamine Hydrobromide Galanthamine Extract
Galantamine is used for the treatment of mild to moderate Alzheimers disease and various other memory impairments, in particular those of vascular origin. In addition to uses in Alzheimers disease, galantamine has been used to treat myasthenia, myopathy, muscular dystrophy, and sensory and motor dysfunction associated with disorders of the central nervous system. Research has indicated that galantamine may prove useful both in the treatment of organophosphate poisoning and in the treatment of autism in children and adolescents.
Product Specification: 98% 99% Galanthamine Hydrobromide
Latin Name: Lycoris radiata (L.herit.)
Product Type: White to off-white crystalline powder
Part of the Plant Used: Tuber (Fresh, 100% Natural)
Extract Method: Hydro-alcoholic extraction
Galanthamine CAS#: [1953-04-4]
Molecular Weight: 287.36
Test Item: Appearance, Identification, Residue on Ignition, Specific Rotation, Loss on drying, pH, Solvent Residual, Assay, Ralated Substances
Galanthamine is an effective,competitive and reversible acetylcholine esterase inhibitor,especially used in curing lightly and moderate Alzheimers Disease.
Galanthamine Hydrobromide is the anti-cholinesterase, weak effect. It has strong effect to the central nervous system through the blood brain barrier. It mainly cures the infantile paralysis sequelae, sweeny and myasthenia gravis pseudoparalytica, etc. It also can be applied to puerilism, posttraumatic apoplexy, polyneuritis and radiculitis.
Clinic function: mainly used in myasthenia gravis, poliovirus quiescent stage and sequela, also in polyneuritis, funiculitis and sensorimotor barrier caused by nervous system disease or traumatism. Its major used in Alzheimers disease, has the principal function for dement and dysmnesia caused by organic brain damage.
Galanthamine Hydrobromide mainly used in myasthenia gravis, poliovirus quiescent stage and sequela, also in polyneuritis, funiculitis and sensorimotor barrier caused by nervous system disease or traumatism. Its major used in Alzheimers disease, has the principal function for dement and dysmnesia caused by organic brain damage.
Galanthamine Biological effects:
Galanthamine extract is specific, competitive and reversible acetylcholinesterase inhibitor. It is also an allosteric modulator at nicotinic cholinergic receptor sites potentiating cholinergic nicotinic neurotransmission. Both the acetylcholine and nicotine receptors have been suggested as areas related to cognitive impairment. Initially, Galanthamine extract was used in anesthesiology to antagonize the effects of non-depolarizing muscle relaxants, and since then it was rapidly introduced in other areas of medicine, i.e. neurology, ophthalmology, gastroenterology, intensive care and resuscitation, cardiology, physiotherapy.
Other neuromuscular diseases
Phase I and II clinical trials for the treatment of MELAS (mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes) and primary progressive multiple sclerosis are ongoing as of December 2013.
Pharmacokinetics of Idebenone
Idebenone is well absorbed from the gut but undergoes excessive first pass metabolism in the liver, so that less than 1% reach the circulation. This rate can be improved with special formulations (suspensions) of idebenone and by administering it together with fat food; but even taking these measures bioavailability still seems to be considerably less than 14% in humans. More than 99% of the circulating drug are bound to plasma proteins. Idebenone metabolites include glucuronides and sulfates, which are mainly (~80%) excreted via the urine.
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Galanthamine 99% Purity Nootropic Pharmaceutical Chemicals Galanthamine Extract Images