Steroidal Estrogen Estriol / E3/ Oestriol / 16α-hydroxyestradiol CAS 50-27-1
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Estriol (E3), or oestriol, also known as 16α-hydroxyestradiol or as estra-1,3,5(10)-triene-3,16α,17β-triol, is a natural steroidal estrogen and one of the three main estrogens in the human body. Production of estriol by the ovaries is almost undetectable in non-pregnant women.However, during pregnancy, estriol is synthesized in very high amounts by the placenta and is by far the most produced estrogen in the body,although circulating levels are similar to those of other estrogens due to a relatively high rate of metabolism and excretion.
Estriol can be a weak or strong estrogen depending on if it is given acutely or chronically when given to immature animals, but is an antagonist when given in combination with estradiol.
Estriol may play a role in the development of breast cancer, but based on in vitro research, does appear to act as an antagonist to the G-protein coupled estrogen receptor. Though estriol is used as part of the primarily North American phenomenon of bioidentical hormone replacement therapy.
storage temp.: -20°C Freezer
MP: 280-282 °C(lit.)
Appearance: White Crystalline Solid
Usage: A metabolite of Estradiol. An estrogenic metabolite considerably less potent than the hormone Estradiol.
Estradiol is produced especially within the follicles of female ovaries, but also in other endocrine (i.e., hormone-producing) and non-endocrine tissues (e.g., including fat, liver, adrenal, breast, and neural tissues). Estradiol is biosynthesized from progesterone (arrived at in two steps from cholesterol, via intermediate pregnenolone). One principle pathway then converts progesterone to its 17-hydroxy-derivative, and then to androstenedione via sequential cytochrome P450-catalyzed oxidations.Action of aromatase on this dione generates estrone, and action of a dehydrogenase on this gives the title compound, 17β-estradiol.
A chemical derivative of estradiol, ethinyl estradiol with maximum dosage 200 µg, is a major component of hormonal contraceptive devices. Combined forms of hormonal contraception contain ethinyl estradiol and a progestin, which both contribute to the inhibition of GnRH, LH, and FSH, which accounts for the ability of these birth control methods to prevent ovulation and thus prevent pregnancy. Other types of hormonal birth control contain only progestins and no ethinyl estradiol.
The typical oral dose used in Western Europe is 2 to 5 mg daily, but because much of it is "dumped" by
the liver immediately, this may only ultimately amount to ½ to 1 mg of estriol actually getting into the body.
Many clinicians use an estriol cream that delivers 2 to 5 mg. When made as a cream, the pharmacist
should indicate on the container how much cream it takes to provide the 2 to 5 mg of estriol.
When you deliver estriol to your body via a cream, it is delivered in a much steadier fashion, whereas given orally it is subject to all the variables of how the digestive system and the liver are working from hour to
An estriol cream that delivers 0.5 mg, used every other day, has been shown to be very effective for treating vaginal atrophy and urinary tract infections. Published studies show that 0.5 mg estriol delivered every other day for 2 weeks, is adequate for most women, and this is how estriol is used by most women in
The reason that estriol is used only every other day is because it doesn clear from the body as fast as the other estrogens and therefore one dose will last for two days. Using it every day can result in excessively high levels. Although estriol does not absorb through the skin as rapidly as estradiol or estrone, studies have shown that topical delivery of estriol is about twenty times more efficient than oral delivery.
1.Estriol is a Safe and Effective Hormone for Menopausal Women with Hot Flashes and Vaginal Dryness
2.Estriol Protects Against Breast and Uterine Cancers
3.Estriol as a Replacement Estrogen in Breast Cancer Survivors
4.Estriol Prevents Vaginal Atrophy and Urinary Tract Infections
5.Estriol Does Not Cause Blood Clots
6.Estriol Protects the Skin From Aging
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Steroidal Estrogen Estriol / E3 / Oestriol / 16α - hydroxyestradiol CAS 50-27-1 Images