Pharma Grade Estrogenic Raw Hormone Powders Estrone / E1 / Oestrone CAS 53-16-7
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CAS NO.: 53-16-7
Molecular Formula: C18H22O2
Molecular Weight: 270.37
Quality Standard: USP31
Packing: Foil bag
Usage: Synthesis of pharmaceutical intermediates is ethinyl estradiol
Estrone (E1, and also oestrone) is an estrogenic hormone secreted by the ovary as well as adipose tissue with the chemical name of 3-hydroxyestra-1,3,5(10)-triene-17-one and the chemical formula C18H22O2. Estrone is an odorless, solid crystalline powder, white in color with a melting point of 254.5 °C and a specific gravity of 1.23.Estrone is one of several natural estrogens, which also include estriol and estradiol. Estrone is the least abundant of the threehormones; estradiol is present almost always in the reproductive female body, and estriol is abundant primarily duringpregnancy.
Estrone is known to be a carcinogen for human females as well as cause breast tenderness or pain, nausea, headache, hypertension, and leg cramps.In men, estrone has been known to cause anorexia, nausea, vomiting, and erectile disfunction. Estrone is relevant to health and disease states because of its conversion to estrone sulfate, a long-lived derivative. Estrone sulfate acts as a reservoir that can be converted as needed to the more active estradiol. It is the predominant estrogen in postmenopausal women.
Estrone was previously marketed in intramuscular and vaginal formulations and was used in the treatment of symptoms of hypoestrogenism such as hot flashes and atrophic vaginitis in menopausal or ovariectomized women.It has since been discontinued and is no longer available, having been superseded by other estrogens with greater potency and improved pharmacokinetics (namely oral bioavailability and duration).Although estrone itself is no longer used medically, other marketed estrogens such as estradiol and estrone sulfate produce estrone as a major metabolite.
Estrone, also known as estra-1,3,5(10)-triene-3-ol-17-one, is a naturally occurring estrane steroid with double bonds at the C1, C3, and C5 positions, a hydroxyl group at the C3 position, and a ketone group at the C17 position. The name estrone was derived from the chemical terms estrin (estra-1,3,5(10)-triene) and ketone.
The chemical formula of estrone is C18H22O2 and its molecular weight is 270.366 g/mol. It is a white, odorless, solid crystalline powder, with a melting point of 254.5 °C (490 °F) and a specific gravity of 1.23.Estrone is combustible at high temperatures, with the products carbon monoxide (CO) and carbon dioxide (CO2).
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Pharma Grade Estrogenic Raw Hormone Powders Estrone / E1 / Oestrone CAS 53-16-7 Images