Based on medical tests, RAD 140 SARM also displayed a greater anabolic effect than testosterone when used. Rad-140, the potent, orally bioavailable and nonsteroidal SARM is designed to make the hormonal receptors in the tissues of the body act the same way as if they’re getting a good dose of testosterone, setting off the same effects as if you’re cycling with prohormones and anabolic steroids minus unwanted side effects.
What is RAD-140 SARM?
To explain the worthwhile use of RAD-140 as opposed to any other steroid, one does need to have a full understanding of the terminology involved:
Agonist - an agonist is a molecule which can enable a receptor. Depending on the strength of the agonist, will determine the effect it can have on a molecule.
Modulator - a type of agonist, but it enables to receptor and molecule to bind to each other. The receptor can cause different reactions in different tissues. This is helpful especially if you want to bulk up in some areas, and not alter the tissue in more sensitive areas like the larynx, scalp lining or even a prostate and a liver.
It basically means that when it comes to Anabolic Steroids, you want to use a product that is not going to have the same general effect all over your body. You want it to work where it needs to, and not in places that it does not need to.
For example, we inject testosterone to cause an androgenic effect in certain tissues but do not want it to cause an androgenic effect in all tissues like your prostate. Ideally the ratio of Anabolic Steroids to Androgenic should be 20:1.
Certain products differ:
- Norbolethone 16:1
- Oxandrolone 12:1
- Norethandrolone 16:1
Whats the RAD-140 Ratio ?
RAD-140 has a ratio of 90:1 which is visibly different to Oxandrolone, Norbolethone and Norethanadrolone. RAD-140 is also one of the many magical steroids that are powerful enough to limit the androgenic effect of testosterone on the prostate and other unwanted areas.
There are still certain avenues that need to be researched in terms of effect on the body, especially for the female sex. Synthetic Anabolic Steroids can have a nasty effect on the larynx and consequently the voice of a woman, as well as the scalp lining.
RAD-140 still has yet to demonstrate its effect in these areas, but the outcome could be completely different to that of synthetic Anabolic Steroids. For men, overall it can be quite useful when stacking because it does not affect the prostate.
Side Effects of RAD 140 SARM
Researches didn find yet any side effects caused by RAD 140 SARM use. However, show maximum caution to dosage. Click here to read the US National Center for Biotechnology Information research on RAD 140.
Dosage for RAD 140 SARM
The recommended dosage of this selective androgen receptor modulator range between 0.3, 3 and 30 milligrams daily. This work great for increasing lean muscle mass and keep you safe. Any dosage higher than this increases the chances of facing health problems.
RAD-140 is indeed very interesting.
First, as to terminology. An “agonist” is a molecule which activates a receptor. A full agonist, at high enough concentration in the blood or test medium, can achieve 100% effect from the receptors. A partial agonist, also called a weak agonist, can only ever achieve partial effect from the receptors. In some cases it binds the receptors, but no activity results. In some cases, the presence of a partial agonist can reduce the effect of a full agonist that is also present. For example, in humans estriol, a weak agonist, can reduce the effect of estradiol, a full agonist.
The concept of a modulator, as opposed to being a simple agonist of some type, is that when the molecule binds to a receptor, in some tissues the receptor will act in one way and in other tissues, a different way.
Tamoxifen (Nolvadex) or clomiphene (Clomid), for example, cause estrogen receptors in breast tissue to work differently than when estradiol binds the receptors, but in bone tissue causes the receptors to work in the same way as when estradiol binds.
So what would be the significance to androgens? In muscle cells we’d want the molecule to work in the same way that testosterone does. But in tissues that we don’t want androgenic effect, ideally we’d want the molecule to work differently at the androgen receptor than testosterone does.
In terms of the most commonly measured effect - levator ani growth vs prostate growth* - we already had this with the synthetic anabolic steroids. The difference in effect was calculated as the anabolic/androgenic ratio. Values for this ratio reached as high as a reported 20:1 with norbolethone, 16:1 with norethandrolone, and 12:1 for oxandrolone.
Ostarine and some others showed anabolic/androgenic ratios comparable to this, though a little better. Differences were arguably more quantitative than being in kind or class, particularly given that the assay method gives quite variable results from one study to another.
It’s a very interesting compound, and could be of value as part of a steroid stack due to its partial testosterone blocking effect in the prostate.
* In the rat, the muscle sometimes called the levator ani acts to elevate the penis. While it responds differently to anabolic steroids than skeletal muscle cells in general do, in the anabolic/androgenic ratio measurements levator ani growth is used as a guess factor for general effect on skeletal muscle growth. Prostate growth provides some useful information on effect on the prostate and is used as a guess factor for effect on other tissues such as the scalp and the larynx, but is of no proven value for estimating effect on those tissues.
RAD-140, however, has shown an anabolic/androgenic ratio of about 90:1, and actually antagonizes (partially blocks) the effect of testosterone on the prostate. That’s an impressive demonstration.
Now as to whether RAD-140 has less activity in the scalp or, for women, the larynx than synthetic anabolic steroids, that would be a differing question which may have a differing outcome.
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