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HONGKONG XINCHENG GONGCHUANG TECHNOLOGY CO., LTD.

HONGKONG XINCHENG GONGCHUANG TECHNOLOGY CO., LTD.

Home > Products > SARMs Steroids > Powder GW-0742 / GW 0742 Selective Androgen Receptor Modulators Muscle Building
 

Powder GW-0742 / GW 0742 Selective Androgen Receptor Modulators Muscle Building

  • Powder GW-0742 / GW 0742 Selective Androgen Receptor Modulators Muscle Building
Place of Origin:
China
Brand Name:
HKYC
Certification:
ISO 9000, SGS
Model Number:

sarms powder

Min.Order Quantity:
10g
Price:
negotiable(best offer will be provided)
Packaging Details:
designed disguised packing ways, 100% pass custom guarantee)
Delivery Time:
within 24hours after payment confirm
Payment Terms:
MoneyGram, Western Union, T/T, Bitcoin
Supply Ability:
1000Kg per Month
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Product Description

SARMs Powder GW-0742 / GW 0742 For Muscle Building CAS: 1196133-39-7

Just try a small order to start our cooperation, we will NOT make you down !
Any products interested pls let me know I will give info.in details.


CAS No.:317318-84-6
Synonyms:GW 0742;
Formula:C21H17F4NO3S2
Exact Mass:471.05900
Molecular Weight:471.48800
PSA:112.96000
LogP:6.34050

Description:

GW0742 is a high affinity PPAR-β/δ agonist reduces lung inflammation induced by bleomycin instillation in mice.


A high throughput screening campaign was conducted to identify small molecules with the ability to inhibit the interaction between the vitamin D receptor (VDR) and steroid receptor coactivator 2. These inhibitors represent novel molecular probes to modulate gene regulation mediated by VDR. The peroxisome proliferator-activated receptor δ (PPARδ) agonist GW0742 was among the identified VDR-coactivator inhibitors and has been characterized herein as a pan nuclear receptor antagonist at concentrations higher than 12.1 µM. The highest antagonist activity for GW0742 was found for VDR and the androgen receptor (AR). Surprisingly, GW0742 behaved as PPAR agonist/antagonist activating transcription at lower concentration and inhibiting this effect at higher concentrations. A unique spectroscopic property of GW0742 was identified as well. In the presence of rhodamine-derived molecules, GW0742+ increased fluorescence intensity and fluorescence polarization at an excitation wavelength of 595 nm and emission wavelength of 615 nm in a dose dependent manner. The GW0742-inhibited NR-coactivator binding resulted in a reduced expression of five different NR target genes in LNCaP cells in the presence of agonist. Especially VDR target genes CYP24A1, IGFBP-3 and TRPV6 were negatively regulated by GW0742. GW0742 is the first VDR ligand inhibitor lacking the secosteroid structure of VDR ligand antagonists. Nevertheless, the VDR-meditated downstream process of cell differentiation was antagonized by GW0742 in HL-60 cells that were pretreated with the endogenous VDR agonist 1,25-dihydroxyvitamin D3.

SARMs List


MK-2866 (Ostarine)
RAD-140 (Testolone)
MK-677 (Ibutamoren; Nutrobal)
LGD-4033 (Ligandrol; Anabolicum)
S4 (Andarine)
SR9009 (Stenabolic)
SR9011
YK11
GW501516(GSK-516)
AICAR
S-23
LGD-3303
GW-0742
MK-1775

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ABOUT US
----------------
Wee specialized in pharma.raw materials ( hormone steroid powders, Steroids injectable liquids,peptides,Sarms), our company integrates R&D, producing, operating and marketing into an organic whole. We have authority of export and import, and have experience of export for 15 years.

Major Market: United States, United Kingdom, Australia, Canada, Sweden, Russia, Poland, Brazil, Israel, Netherlands, Germany,Spain, Switzerland, Poland and so on.

MOQ:10g

Package:Disguised & Discreet pkg
Payment:T/T,Western Union,Moneygram,bitcoin
Delivery: sent out the goods within 24hours after receiving payment.
Custom Pass rate:99%
Resend policy is available if the parcle is seized or any quality problems been found.


After-sale Service :
Discounts are available for our second-time customers. We can provide recipes and professional suggestions to promote yourselves. Tracking number and packing photos can be given quickly after your goods sent. We are always here waiting for you!

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